Regulation of actin dynamics by annexin 2.

  title={Regulation of actin dynamics by annexin 2.},
  author={Matthew J. Hayes and Dongmin Shao and Maryse Bailly and Stephen E Moss},
  journal={The EMBO journal},
  volume={25 9},
Annexin 2 is a ubiquitous Ca(2+)-binding protein that is essential for actin-dependent vesicle transport. Here, we show that in spontaneously motile cells annexin 2 is concentrated in dynamic actin-rich protrusions, and that depletion of annexin 2 using siRNA leads to the accumulation of stress fibres and loss of protrusive and retractile activity. Cells co-expressing annexin 2-CFP and actin-YFP exhibit Ca(2+)-dependent fluorescense resonance energy transfer throughout the cytoplasm and in… CONTINUE READING
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Annexins: linking calcium signaling to membrane function

  • V Gerke, CE Creutz, SE Moss
  • Nat Rev Mol Cell Biol
  • 2005
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