Regulation of actin assembly associated with protrusion and adhesion in cell migration.

@article{Clainche2008RegulationOA,
  title={Regulation of actin assembly associated with protrusion and adhesion in cell migration.},
  author={Christophe Le Clainche and M Carlier},
  journal={Physiological reviews},
  year={2008},
  volume={88 2},
  pages={489-513}
}
To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this process. The first part of this review (sect. II) describes the formation of the lamellipodial and filopodial actin networks. In lamellipodia, the WASP-Arp2/3 pathways generate a branched filament array. This polarized dendritic actin array is maintained in rapid treadmilling by the concerted action of ADF, profilin… CONTINUE READING