Regulation of acetylcholinesterase secretion from neuronal cell cultures.--1. Actions of nerve growth factor, cytoskeletal inhibitors and tunicamycin.

@article{Lucas1985RegulationOA,
  title={Regulation of acetylcholinesterase secretion from neuronal cell cultures.--1. Actions of nerve growth factor, cytoskeletal inhibitors and tunicamycin.},
  author={Carlos Alvarez Lucas and Georg W. Kreutzberg},
  journal={Neuroscience},
  year={1985},
  volume={14 1},
  pages={349-60}
}
The release of enzymatically active acetylcholinesterase was measured from two types of neuronal cell cultures. Evidence is presented that primary cultures of chick optic lobe and clonal rat PC12 cells released acetylcholinesterase by similar mechanisms. The secretion was selective for the tetrameric or larger molecule forms of acetylcholinesterase. Thus the chick primary cultures released the so-called G4 isoenzyme of acetylcholinesterase. The rat PC12 cells, after pretreatment with nerve… CONTINUE READING