Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

@article{Sonoda2002RegulationOA,
  title={Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).},
  author={Junichiro Sonoda and Wen Xie and John M Rosenfeld and Joyce L. Barwick and Philip S. Guzelian and Ronald M Evans},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 21},
  pages={13801-6}
}
The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. We found that activation of PXR also increases the activity and gene expression of the phase II conjugating enzyme dehydroepiandrosterone sulfotransferase (STD) known to sulfate LCA to facilitate its elimination. This activation is direct and appears to… CONTINUE READING
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