Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.

  title={Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.},
  author={Emmanuel Valjent and Vincent Jean Pascoli and Per Svenningsson and Surojit Paul and Herv{\'e} Enslen and Jean-Christophe Corvol and Alexandre Stipanovich and Jocelyne Caboche and Paul J. Lombroso and Angus C. Nairn and Paul Greengard and Denis Herv{\'e} and Jean-Antoine Girault},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 2},
Many drugs of abuse exert their addictive effects by increasing extracellular dopamine in the nucleus accumbens, where they likely alter the plasticity of corticostriatal glutamatergic transmission. This mechanism implies key molecular alterations in neurons in which both dopamine and glutamate inputs are activated. Extracellular signal-regulated kinase (ERK), an enzyme important for long-term synaptic plasticity, is a good candidate for playing such a role. Here, we show in mouse that d… CONTINUE READING
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