Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers.

  title={Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers.},
  author={Sharon Mexal and Ralph Berger and Lucy Pearce and Amanda Barton and J. D. Logel and Catherine E. Adams and Randal Glenn Ross and Robert Freedman and Sherry Leonard},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  volume={147B 6},
The alphaN-catenin (CTNNA2) gene represents a promising candidate gene for schizophrenia based upon previous genetic linkage, expression, and mouse knockout studies. CTNNA2 is differentially regulated by smoking in schizophrenic patients. In this report, the genomic structure of a primate-specific alphaN-catenin splice variant (alphaN-catenin III) is described. A comparison of alphaN-catenin III mRNA expression across postmortem hippocampi from schizophrenic and non-mentally ill smokers and non… CONTINUE READING


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