Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion

@article{Johnston2000RegulationOA,
  title={Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion},
  author={Imogen MP Johnston and Heather J. Spence and Joseph N Winnie and Lynn McGarry and J. Keith Vass and Liam Meagher and Genevieve Stapleton and Bradford W. Ozanne},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={5348-5358}
}
The transcription factor AP-1 (activator protein-1) is required for transformation by many oncogenes, which function upstream of it in the growth factor-ras signal transduction pathway. Previously, we proposed that one role of AP-1 in transformation is to regulate the expression of a multigenic invasion programme. As a test of this proposal we sought to identify AP-1 regulated genes based upon their differential expression in 208F rat fibroblasts transformed by FBR-v-fos (FBR), and to determine… CONTINUE READING

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