Regulation of a distinctive set of genes in glucocorticoid-evoked apoptosis in CEM human lymphoid cells.

@article{Thompson2003RegulationOA,
  title={Regulation of a distinctive set of genes in glucocorticoid-evoked apoptosis in CEM human lymphoid cells.},
  author={E Brad Thompson and Betty H. Johnson},
  journal={Recent progress in hormone research},
  year={2003},
  volume={58},
  pages={175-97}
}
Gene expression was evaluated in clones of the acute lymphoblastic leukemic cell line CEM that were sensitive or resistant to apoptosis evoked by the glucocorticoid, dexamethasone (Dex). Founding clones CEM-C7 (glucocorticoid sensitive) and CEM-C1 (glucocorticoid resistant) were subcloned to maximize uniformity of each population studied. Among subclones of C1, our original pseudodiploid clone of glucocorticoid-resistant cells, we found a high proportion of hyperploid clones. Most C1 subclones… CONTINUE READING

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Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes

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