Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

@article{Kaeberlein2005RegulationOY,
  title={Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients},
  author={M. Kaeberlein and R. Powers and K. Steffen and Eric A. Westman and Di Hu and N. Dang and Emily O. Kerr and Kathryn T Kirkland and S. Fields and B. Kennedy},
  journal={Science},
  year={2005},
  volume={310},
  pages={1193 - 1196}
}
Calorie restriction increases life span in many organisms, including the budding yeast Saccharomyces cerevisiae. [...] Key Result From a large-scale analysis of 564 single-gene-deletion strains of yeast, we identified 10 gene deletions that increase replicative life span. Six of these correspond to genes encoding components of the nutrient-responsive TOR and Sch9 pathways.Expand
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