Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells.

@article{Ku2009RegulationOX,
  title={Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells.},
  author={Sebastian Chih Yuan Ku and Poh Choo Toh and Yih Yean Lee and Janet Chusainow and Miranda Gek Sim Yap and Sheng-Hao Chao},
  journal={Biotechnology progress},
  year={2009},
  volume={26 2},
  pages={
          517-26
        }
}
X-box binding protein 1 (XBP-1) is a key regulator of cellular unfolded protein response (UPR). The spliced isoform of XBP-1, XBP-1S, is a transcription activator, which is expressed only when UPR is induced. However, the impact of recombinant protein production on the regulation of XBP-1 signaling in CHO cells is not well understood. In this report, we cloned the Chinese hamster XBP-1 homolog to aid the investigation of the interplay between protein productivity, culture conditions, and… CONTINUE READING
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