Regulation of X-chromosome inactivation by the X-inactivation centre

@article{Augui2011RegulationOX,
  title={Regulation of X-chromosome inactivation by the X-inactivation centre},
  author={Sandrine Augui and Elph{\`e}ge P. Nora and Edith Heard},
  journal={Nature Reviews Genetics},
  year={2011},
  volume={12},
  pages={429-442}
}
X-chromosome inactivation (XCI) ensures dosage compensation in mammals and is a paradigm for allele-specific gene expression on a chromosome-wide scale. Important insights have been made into the developmental dynamics of this process. Recent studies have identified several cis- and trans-acting factors that regulate the initiation of XCI via the X-inactivation centre. Such studies have shed light on the relationship between XCI and pluripotency. They have also revealed the existence of dosage… CONTINUE READING

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