Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase.

  title={Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase.},
  author={Gurtej K. Dhoot and Marcus K Gustafsson and Xingbin Ai and Wanping Sun and D M Standiford and Charles P. Emerson},
  volume={293 5535},
The developmental signaling functions of cell surface heparan sulfate proteoglycans (HSPGs) are dependent on their sulfation states. Here, we report the identification of QSulf1, the avian ortholog of an evolutionarily conserved protein family related to heparan-specific N-acetyl glucosamine sulfatases. QSulf1 expression is induced by Sonic hedgehog in myogenic somite progenitors in quail embryos and is required for the activation of MyoD, a Wnt-induced regulator of muscle specification. QSulf1… CONTINUE READING
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