Regulation of WRN helicase activity in human base excision repair.

  title={Regulation of WRN helicase activity in human base excision repair.},
  author={Byungchan Ahn and Jeanine A. Harrigan and Fred. E. Indig and David M. Wilson and Vilhelm A. Bohr},
  journal={The Journal of biological chemistry},
  volume={279 51},
Werner syndrome patients are deficient in the Werner protein (WRN), which is a multifunctional nuclear protein possessing 3'-5' exonuclease and ATP-dependent helicase activities. Studies of Werner syndrome cells and biochemical studies of WRN suggest that WRN plays a role in several DNA metabolic pathways. WRN interacts with DNA polymerase beta (pol beta) and stimulates pol beta strand displacement synthesis on a base excision repair (BER) intermediate in a helicase-dependent manner. In this… CONTINUE READING