Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.

@article{McGuire2016RegulationOV,
  title={Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness.},
  author={Christina M McGuire and Kristina Cotter and Laura A Stransky and Michael Forgac},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1857 8},
  pages={1213-1218}
}
V-ATPases are ATP-driven proton pumps that function within both intracellular compartments and the plasma membrane in a wide array of normal physiological and pathophysiological processes. V-ATPases are composed of a peripheral V(1) domain that hydrolyzes ATP and an integral V(0) domain that transports protons. Regulated assembly of the V-ATPase represents an important mechanism of regulating V-ATPase activity in response to a number of environmental cues. Our laboratory has demonstrated that… CONTINUE READING
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