Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.

@article{Sikes2002RegulationOV,
  title={Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.},
  author={Michael L. Sikes and Amber Meade and Rajkamal Tripathi and Michael S Krangel and Eugene M. Oltz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 19},
  pages={12309-14}
}
Antigen receptor gene assembly is regulated by transcriptional promoters and enhancers, which control the accessibility of gene segments to a lymphocyte-specific V(D)J recombinase. However, it remained unclear whether accessibility depends on the process of transcription itself or chromatin modifications that accompany transcription. By using T cell receptor beta substrates that integrate stably into nuclear chromatin, we show that promoter location, rather than germ-line transcription or… CONTINUE READING

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