Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis.

  title={Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis.},
  author={Lin Zhou and Xiaodi Zhao and Yanan Han and Yuanyuan Lu and Yulong Shang and Changhao Liu and Ting Li and Zhian Jin and Dai-ming Fan and Kaichun Wu},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={27 12},
Epigenetic changes play significant roles in the development of cancer. UHRF1, as an epigenetic regulator, has been shown to be overexpressed and to coordinate tumor suppressor gene silencing in several cancers. However, the role and underlying mechanism of UHRF1 in gastric cancer (GC) progression remain largely unknown. In this study, we investigated the expression and function of UHRF1 in GC metastasis and explored its upstream regulatory mechanisms at the microRNA level. UHRF1 was… CONTINUE READING


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