Regulation of Two Renal Chloride Transporters, AE1 and Pendrin, by Electrolytes and Aldosterone

@inproceedings{Mohebbi2013RegulationOT,
  title={Regulation of Two Renal Chloride Transporters, AE1 and Pendrin, by Electrolytes and Aldosterone},
  author={Nilufar Mohebbi and Angelica Perna and Jenny van der Wijst and Helen Becker and Giovambattista Capasso and Carsten A Wagner},
  booktitle={PloS one},
  year={2013}
}
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate. In the collecting duct, the regulated fine-tuning of salt and acid-base homeostasis is achieved by a series of transport proteins located in different cell types, intercalated and principal cells. Intercalated cells are considered to be of less importance for salt handling but recent evidence has suggested that the anion exchanger… CONTINUE READING

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NaCl or KHCO₃ increased pendrin mRNA , KCl decreased its mRNA abundance .
On protein level , NH₄Cl , NaCl , and KCl reduced pendrin expression , the other treatments were without effect .
NaCl or KHCO₃ increased pendrin mRNA , KCl decreased its mRNA abundance .
On protein level , NH₄Cl , NaCl , and KCl reduced pendrin expression , the other treatments were without effect .
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium , chloride , protons , and bicarbonate .
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium , chloride , protons , and bicarbonate .
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium , chloride , protons , and bicarbonate .
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium , chloride , protons , and bicarbonate .
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