Regulation of Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT, PIASy through Smad3*

@article{Imoto2003RegulationOT,
  title={Regulation of Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT, PIASy through Smad3*},
  author={S. Imoto and K. Sugiyama and R. Muromoto and N. Sato and Tetsuya Yamamoto and T. Matsuda},
  journal={Journal of Biological Chemistry},
  year={2003},
  volume={278},
  pages={34253 - 34258}
}
Smads proteins play a key role in the intracellular signaling of the transforming growth factor (TGF)-β family of growth factors, which exhibits a diverse set of cellular responses, including cell proliferation and differentiation. In particular, Smad7 acts as an antagonist of TGF-β signaling, which could determine the intensity or duration of its signaling cascade. In this study we identified a protein inhibitor of activated STAT (signal transducers and activators of transcription), PIASy, as… Expand
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