Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo.

@article{Zhang2007RegulationOT,
  title={Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo.},
  author={Xinhua Zhang and Yuko Kimura and Chongyun Fang and Lin Zhou and Georgia Sfyroera and John D. Lambris and Rick A Wetsel and Takashi Miwa and Wen-chao Song},
  journal={Blood},
  year={2007},
  volume={110 1},
  pages={228-36}
}
Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact with each other has not been well studied. We demonstrate here a widespread regulation of TLR signaling by complement in vivo. The TLR ligands lipopolysacharride (TLR4), zymosan… CONTINUE READING

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