Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway

  title={Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway},
  author={Kevin I. Watt and Kieran F. Harvey and Paul Gregorevic},
  booktitle={Front. Physiol.},
The integrative control of diverse biological processes such as proliferation, differentiation, apoptosis and metabolism is essential to maintain cellular and tissue homeostasis. Disruption of these underlie the development of many disease states including cancer and diabetes, as well as many of the complications that arise as a consequence of aging. These biological outputs are governed by many cellular signaling networks that function independently, and in concert, to convert changes in… CONTINUE READING
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