Regulation of Thyroid Hormone Bioactivity in Health and Disease

@inproceedings{Peeters2005RegulationOT,
  title={Regulation of Thyroid Hormone Bioactivity in Health and Disease},
  author={Robin Patrick Peeters},
  year={2005}
}
Introduction: Single nucleotide polymorphisms (SNPs) in genes involved in thyroid hormone metabolism may a ect thyroid hormone bioactivity. We investigated the occurrence and possible e ects of SNPs in the deiodinases (D1-D3), the TSH receptor (TSHR), and the T3 receptor β (TRβ) genes. Methods: SNPs were identi ed in public databases or by sequencing of genomic DNA from 15 randomly selected subjects (30 alleles). Genotypes for the identi ed SNPs were determined in 156 healthy blood donors and… CONTINUE READING

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