Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

@article{Beurel2013RegulationOT,
  title={Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.},
  author={El{\'e}onore Beurel and Oksana Kaidanovich-Beilin and Wen-I Yeh and Ling Song and Valle Palomo and Suzanne M. Michalek and James R Woodgett and Laurie E Harrington and Hagit Eldar-Finkelman and Ana Mercedes Victoria Mart{\'i}nez and Richard Scott Jope},
  journal={Journal of immunology},
  year={2013},
  volume={190 10},
  pages={5000-11}
}
Experimental autoimmune encephalomyelitis (EAE) is a rodent model of multiple sclerosis (MS), a debilitating autoimmune disease of the CNS, for which only limited therapeutic interventions are available. Because MS is mediated in part by autoreactive T cells, particularly Th17 and Th1 cells, in the current study, we tested whether inhibitors of glycogen synthase kinase-3 (GSK3), previously reported to reduce Th17 cell generation, also alter Th1 cell production or alleviate EAE. GSK3 inhibitors… CONTINUE READING

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