Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae

@inproceedings{Kaizer2015RegulationOT,
  title={Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae},
  author={Hannah Kaizer and Carla J. Connelly and Kelsey E Bettridge and Christopher Viggiani and Carol W Greider},
  booktitle={Genetics},
  year={2015}
}
The regulation of telomere length equilibrium is essential for cell growth and survival since critically short telomeres signal DNA damage and cell cycle arrest. While the broad principles of length regulation are well established, the molecular mechanism of how these steps occur is not fully understood. We mutagenized the RIF2 gene in Saccharomyces cerevisiae to understand how this protein blocks excess telomere elongation. We identified an N-terminal domain in Rif2 that is essential for… CONTINUE READING

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