Regulation of Tau Gene Expression by AP and the Amyloid Precursor Protein in Cultured Cortical Neurons


The two characteristic lesions of Alzheimer's disease are intracellular neurofibrillary tangles and extracellular accumulation of amyloid plaques. Tangles are composed of abnormally hyper-phosphorylated forms of the microtubule-associated protein tau, whereas amyloid (AP) is derived from proteolytic processing of the amyloid precursor protein (APP). These… (More)


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