Regulation of TRP channels: a voltage-lipid connection.

  title={Regulation of TRP channels: a voltage-lipid connection.},
  author={Bernd Nilius and F Mahieu and Yuji Karashima and Thomas Voets},
  journal={Biochemical Society transactions},
  volume={35 Pt 1},
TRP (transient receptor potential) channels respond to a plethora of stimuli in a fine-tuned manner. We show here that both membrane potential and the level of PI (phosphatidylinositol) phosphates are efficient regulators of TRP channel gating. Recent work has shown that this regulation applies to several members of the TRPV (TRP vanilloid) subfamily (TRPV1 and TRPV5) and the TRPM (TRP melastatin) subfamily (TRPM4/TRPM5/TRPM7/TRPM8), whereas regulation of members of the TRPC subfamily is still… CONTINUE READING