Regulation of TORC1 by Rag GTPases in nutrient response

@inproceedings{Kim2008RegulationOT,
  title={Regulation of TORC1 by Rag GTPases in nutrient response},
  author={Eunjung Kim and Pankuri Goraksha-Hicks and Li Li and Thomas P Neufeld and Kun-Liang Guan},
  booktitle={Nature Cell Biology},
  year={2008}
}
TORC1 (target of rapamycin complex 1) has a crucial role in the regulation of cell growth and size. A wide range of signals, including amino acids, is known to activate TORC1. Here, we report the identification of Rag GTPases as activators of TORC1 in response to amino acid signals. Knockdown of Rag gene expression suppressed the stimulatory effect of amino acids on TORC1 in Drosophila melanogaster S2 cells. Expression of constitutively active (GTP-bound) Rag in mammalian cells activated TORC1… CONTINUE READING
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