Regulation of TLR7/9 signaling in plasmacytoid dendritic cells

  title={Regulation of TLR7/9 signaling in plasmacytoid dendritic cells},
  author={Musheng Bao and Yong-Jun Liu},
  journal={Protein & Cell},
Plasmacytoid dendritic cells (pDCs), also known as type I interferon (IFN)-producing cells, are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nucleic acids derived from virus, bacteria or dead cells. PDCs selectively express endosomal Toll-like receptor (TLR) 7 and TLR9, which sense viral RNA and DNA respectively. Following type I IFN and cytokine responses, pDCs differentiate into antigen presenting cells and… CONTINUE READING


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The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

  • D.M
  • Nat Immunol
  • 2011
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