Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung

@article{Leppranta2012RegulationOT,
  title={Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung},
  author={Outi Lepp{\"a}ranta and Carla Sens and Kaisa Salmenkivi and Vuokko L. Kinnula and Jorma Keski-Oja and Marjukka Myll{\"a}rniemi and Katri Koli},
  journal={Cell and Tissue Research},
  year={2012},
  volume={348},
  pages={491-503}
}
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of unknown cause. The pathogenesis of the disease is characterized by fibroblast accumulation and excessive transforming growth factor-β (TGF-β) activation. Although TGF-β activation is a complex process involving various protein interactions, little is known of the specific routes of TGF-β storage and activation in human lung. Here, we have systematically analyzed the expression of specific proteins involved in extracellular matrix… CONTINUE READING
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ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis

  • M Selman, RF Dudden, BS Griss, SL Protzko, HJ Schunemann
  • Am J Respir Crit Care Med
  • 2011

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