Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

  title={Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination},
  author={Feng Xie and Zhengkui Zhang and Hans van Dam and Long Zhang and Fangfang Zhou},
TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their downstream effectors, the SMAD(drosophila mothers against decapentaplegic protein) proteins. Numerous studies have already demonstrated crucial regulatory roles for modification of TGF-β pathway components by poly-ubiquitination. Recently, several… CONTINUE READING
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