Regulation of TGFβ receptor trafficking and signaling by atypical protein kinase C.

@article{Gunaratne2012RegulationOT,
  title={Regulation of TGFβ receptor trafficking and signaling by atypical protein kinase C.},
  author={Adrian Gunaratne and Hassina Benchabane and Gianni M. Di Guglielmo},
  journal={Cellular signalling},
  year={2012},
  volume={24 1},
  pages={
          119-30
        }
}
Transforming growth factor beta (TGFβ) signaling is linked to the membrane trafficking of TGFβ receptors. The Protein Kinase C (PKC) family of serine/threonine kinases have been implicated in modulating the endocytic processes of various receptors. The present study investigated whether PKC activity plays a role in the trafficking, and signaling of TGFβ receptors, and further explored which PKC isoforms may be responsible for altered TGFβ signaling patterns. Using immunofluorescence microscopy… CONTINUE READING
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