Regulation of TFF3 expression by homeodomain protein CDX2

@article{Shimada2007RegulationOT,
  title={Regulation of TFF3 expression by homeodomain protein CDX2},
  author={Tadahito Shimada and Takero Koike and Michiko Yamagata and Masashi Yoneda and Hideyuki Hiraishi},
  journal={Regulatory Peptides},
  year={2007},
  volume={140},
  pages={81-87}
}
Although trefoil factor family 3 (TFF3) plays an important role in protecting the intestinal mucosa, the regulatory mechanisms of its expression are not fully understood. Since homeodomain protein CDX2 has been reported to be critically involved in the development and differentiation of intestinal epithelium, we examined whether CDX2 affects the expression of TFF3. The transcription of human TFF3 reporter genes was significantly up-regulated by the transient overexpression of CDX2 in COS-7… CONTINUE READING

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