Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.

  title={Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.},
  author={Marie Malissen and Jeannine Trucy and Evelyne Jouvin-Marche and Pierre Andr{\'e} Cazenave and Roland Scollay and Bernard Malissen},
  journal={Immunology today},
  volume={13 8},
Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements. 

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