Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.

@article{KondilisMangum2011RegulationOT,
  title={Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.},
  author={Hrisavgi D. Kondilis-Mangum and Han-Yu Shih and Grace K. Mahowald and Barry P Sleckman and Michael S Krangel},
  journal={Journal of immunology},
  year={2011},
  volume={187 12},
  pages={6374-81}
}
Ag receptor loci are regulated to promote allelic exclusion, but the mechanisms are not well understood. Assembly of a functional TCR β-chain gene triggers feedback inhibition of V(β)-to-DJ(β) recombination in double-positive (DP) thymocytes, which correlates with reduced V(β) chromatin accessibility and a locus conformational change that separates V… CONTINUE READING