Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.

@article{Zhong2002RegulationOT,
  title={Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.},
  author={Xiao-Ping Zhong and Ehmonie A. Hainey and Benjamin A. Olenchock and Haoran Zhao and Matthew K. Topham and Gary A Koretzky},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={31089-98}
}
T cell development in the thymus and activation of mature T cells in the periphery depend on signals stimulated by engagement of the T cell antigen receptor (TCR). Among the second messenger cascades initiated by TCR ligation include the phosphatidylinositol pathway where the membrane phospholipid, phosphatidylinositol 4,5-bisphosphate, is hydrolyzed to inositol 1,4,5-trisphosphate and diacylglycerol (DAG). Inositol 1,4,5-trisphosphate signals a rise in intracellular free calcium, leading to… CONTINUE READING

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