Regulation of T cell receptor CD3zeta chain expression by L-arginine.

  title={Regulation of T cell receptor CD3zeta chain expression by L-arginine.},
  author={P Cabanas Rodr{\'i}guez and Arnold H. Zea and Kirk S. Culotta and Jovanny Zabaleta and Juan B. Ochoa and Augusto Ochoa},
  journal={The Journal of biological chemistry},
  volume={277 24},
L-Arg plays a central role in the normal function of several organ systems including the immune system. L-Arg can be depleted by arginase I produced by macrophages and hepatocytes in several disease states such as trauma and sepsis and following liver transplantation. The decrease in L-Arg levels induces a profound decrease in T cell function through mechanisms that have remained unclear. The data presented here demonstrate that Jurkat T cells cultured in medium without L-Arg (L-Arg-free RPMI… CONTINUE READING