Regulation of T-cell functions by L-lactate.

  title={Regulation of T-cell functions by L-lactate.},
  author={Wulf Dr{\"o}ge and St{\'e}phanie Roth and A. Altmann and Sabine Mihm},
  journal={Cellular immunology},
  volume={108 2},
Lactate is a product of glycolytically active macrophages. After stimulation with concanavalin A accessory cell-depleted splenic T-cell populations were found to produce only minute amounts of T-cell growth factor (TCGF); but substantial amounts of TCGF were produced if the cultures were supplemented either with splenic adherent cells or with lactate but not with interleukin-1 (IL-1). IL-1 was capable, however, of supporting TCGF production by the thymoma subline EL4-6.1. TCGF production in… CONTINUE READING