Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.

@article{Mnasch2007RegulationOT,
  title={Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.},
  author={Ga{\"e}l M{\'e}nasch{\'e} and Stefanie Kliche and Natalie A. Bezman and Burkhart Schraven},
  journal={Immunological reviews},
  year={2007},
  volume={218},
  pages={82-91}
}
Integrins are critical for the migration of T cells to lymphoid organs and to sites of inflammation and are also necessary for productive interactions between T cells and antigen-presenting cells. Integrin activation is enhanced following T-cell receptor (TCR) engagement, as signals initiated by the TCR increase affinity and avidity of integrins for their ligands. This process, known as inside-out signaling, has been shown to require several molecular components including the cytosolic adapter… CONTINUE READING

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