Regulation of T cell activation, anxiety, and male aggression by RGS2.

@article{OliveiradosSantos2000RegulationOT,
  title={Regulation of T cell activation, anxiety, and male aggression by RGS2.},
  author={Antonio J. Oliveira-dos-Santos and Gaku Matsumoto and Bryan E. Snow and Donglin Bai and Frank P. Houston and Ian Q. Whishaw and Sanjeev Mariathasan and Takehiko Sasaki and Andrew C Wakeham and Pamela S. Ohashi and John C. Roder and Carol A. Barnes and David P Siderovski and Josef M. Penninger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 22},
  pages={
          12272-7
        }
}
  • Antonio J. Oliveira-dos-Santos, Gaku Matsumoto, +11 authors Josef M. Penninger
  • Published in
    Proceedings of the National…
    2000
  • Biology, Medicine
  • Regulators of G protein signaling (RGS) proteins accelerate the GTPase activity of Galpha protein subunits in vitro, negatively regulating G protein-coupled receptor signaling. The physiological role of mammalian RGS proteins is largely unknown. The RGS family member rgs2 was cloned as an immediate early response gene up-regulated in T lymphocytes after activation. To investigate the role of RGS2 in vivo, we generated rgs2-deficient mice. We show that targeted mutation of rgs2 in mice leads to… CONTINUE READING

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