Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans

Abstract

Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph nodes, whereas P- and E-selectin capture activated T cells on inflamed vascular endothelium to initiate… (More)
DOI: 10.3389/fimmu.2017.00600

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