Regulation of Synaptic Vesicle Docking by Different Classes of Macromolecules in Active Zone Material

@inproceedings{Szule2012RegulationOS,
  title={Regulation of Synaptic Vesicle Docking by Different Classes of Macromolecules in Active Zone Material},
  author={Joseph A. Szule and Mark Harlow and Jae Hoon Jung and Francisco F. De-Miguel and Robert M. Marshall and U J Mcmahan},
  booktitle={PloS one},
  year={2012}
}
The docking of synaptic vesicles at active zones on the presynaptic plasma membrane of axon terminals is essential for their fusion with the membrane and exocytosis of their neurotransmitter to mediate synaptic impulse transmission. Dense networks of macromolecules, called active zone material, (AZM) are attached to the presynaptic membrane next to docked vesicles. Electron tomography has shown that some AZM macromolecules are connected to docked vesicles, leading to the suggestion that AZM is… CONTINUE READING

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