Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

  title={Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs},
  author={Henry Markram and Joachim H. R. L{\"u}bke and Michael Frotscher and Bert J. Sakmann},
  pages={213 - 215}
Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations… 

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