Regulation of Synapse Structure and Function by the Drosophila Tumor Suppressor Gene dlg

  title={Regulation of Synapse Structure and Function by the Drosophila Tumor Suppressor Gene dlg},
  author={Vivian Budnik and Y C Koh and Bo Guan and Beate Hartmann and Colleen Hough and Daniel Woods and Michael Gorczyca},
Mutations of the tumor suppressor gene discs-large (dlg) lead to postsynaptic structural defects. Here, we report that mutations in dlg also result in larger synaptic currents at fly neuromuscular junctions. By selectively targeting DLG protein to either muscles or motorneurons using Gal-4 enhancer trap lines, we were able to rescue substantially the reduced postsynaptic structure in mutants. Rescue of the physiological defect was accomplished by presynaptic, but not postsynaptic targeting… CONTINUE READING
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