Regulation of Spo12 Phosphorylation and Its Essential Role in the FEAR Network

  title={Regulation of Spo12 Phosphorylation and Its Essential Role in the FEAR Network},
  author={Brett N. Tomson and Rami Rahal and Vladim{\'i}r Reiser and Fernando Monje-Casas and Karim Mekhail and Danesh Moazed and Angelika Amon},
  journal={Current Biology},
BACKGROUND In budding yeast, the protein phosphatase Cdc14 coordinates late mitotic events and triggers exit from mitosis. During early anaphase, Cdc14 is activated by the FEAR network, but how signaling through the FEAR network occurs is poorly understood. RESULTS We find that the FEAR network component Spo12 is phosphorylated on S118. This phosphorylation is essential for Spo12 function and is restricted to early anaphase, when the FEAR network is active. The anaphase-specific… CONTINUE READING
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