Regulation of Sodium Channel Function by Bilayer Elasticity : The Importance of Hydrophobic Coupling . Effects of Micelle-forming Amphiphiles and Cholesterol

Abstract

Membrane proteins are regulated by the lipid bilayer composition. Specific lipid–protein interactions rarely are involved, which suggests that the regulation is due to changes in some general bilayer property (or properties). The hydrophobic coupling between a membrane-spanning protein and the surrounding bilayer means that protein conformational changes… (More)

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