Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway.

Abstract

Hedgehog (Hh) signaling plays a central role in development and diseases. Hh activates its signal transducer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphorylation, but whether Smo is activated through other post-translational modifications remains unexplored. Here we show that sumoylation acts in parallel with phosphorylation to promote… (More)
DOI: 10.1016/j.devcel.2016.09.014

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