Regulation of Smad signaling by protein kinase C

@article{Yakymovych2001RegulationOS,
  title={Regulation of Smad signaling by protein kinase C},
  author={I. Yakymovych and P. Dijke and C. Heldin and S. Souchelnytskyi},
  journal={The FASEB Journal},
  year={2001},
  volume={15},
  pages={553 - 555}
}
Cross talk between transforming growth factor β (TGF‐β) serine/threonine kinase receptor signaling and tyrosine kinase receptor signaling modulates cell responsiveness to polypeptide growth factors regulating cell proliferation, differentiation, and apoptosis. Here we provide a mechanism through which Smad‐dependent TGF‐β signaling is modulated by protein kinase C (PKC). PKC, for example, is activated downstream of tyrosine kinase receptors. We show that PKC directly phosphorylates receptor… Expand
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