Regulation of Sister Chromatid Cohesion between Chromosome Arms

Abstract

Sister chromatid separation in anaphase depends on the removal of cohesin complexes from chromosomes. In vertebrates, the bulk of cohesin is already removed from chromosome arms during prophase and prometaphase, whereas cohesin remains at centromeres until metaphase, when cohesin is cleaved by the protease separase. In unperturbed mitoses, arm cohesion… (More)
DOI: 10.1016/j.cub.2004.06.052

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