Regulation of Sialomucin Complex Expression and Its Effect on HER Receptor Interaction

@inproceedings{Idris2000RegulationOS,
  title={Regulation of Sialomucin Complex Expression and Its Effect on HER Receptor Interaction},
  author={Nebila Idris and Kermit L. Iii Carraway},
  year={2000}
}
Abstract : Sialomucin complex (SMC) is a heterodimeric glycoprotein complex consisting of a mucin subunit ASGP-1 and a transmembrane subunit ASGP-2, which is highly overexpressed on the surface of ascites 13762 rat mammary adenocarcinoma cells. ASGP-2 appears to be a ligand for the growth factor receptor Erb(beta)-2. In normal rat mammary gland the levels of both SMC and Erb(beta)-2 are sharply increased during pregnancy, In normal cultured mammary epithelial cells (MEC) SMC is post… CONTINUE READING

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