Regulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury

@inproceedings{Yi2016RegulationOS,
  title={Regulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury},
  author={Sheng Yi and Ying Yuan and Qianqian Chen and Xinghui Wang and Leilei Gong and Jie Liu and Xiaosong Gu and Shiying Li},
  booktitle={Scientific reports},
  year={2016}
}
Peripheral nerve injury is a global problem that causes disability and severe socioeconomic burden. Brain-derived neurotrophic factor (BDNF) benefits peripheral nerve regeneration and becomes a promising therapeutic molecule. In the current study, we found that microRNA-1 (miR-1) directly targeted BDNF by binding to its 3'-UTR and caused both mRNA degradation and translation suppression of BDNF. Moreover, miR-1 induced BDNF mRNA degradation primarily through binding to target site 3 rather than… CONTINUE READING
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The authors declare no competing financial interests

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  • 2016

Differential gene expression profiling and biological process analysis in proximal nerve segments after sciatic nerve transection

  • S Li
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