Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron.

  title={Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron.},
  author={Laran T. Jensen and Valeria C Culotta},
  journal={Journal of molecular biology},
  volume={318 2},
Saccharomyces cerevisiae expresses two distinct iron transport systems under aerobic and anaerobic conditions. The high affinity transporters, Ftr1p and Fet3p, are primarily expressed in oxygenated cultures, whereas anaerobic conditions induce the low affinity iron transporter, Fet4p. The oxygen regulation of FET4 was found to involve the Rox1p transcriptional repressor. The physiological significance of this control by Rox1p is twofold. First, FET4 repression by Rox1p under oxygenated… CONTINUE READING